The trial court rendered judgment on the jury’s verdict and ordered the corporation to purchase Plaintiff’s shares for $7.3 million. The jury found in Plaintiff’s favor on essentially all of her claims.
The results indicated that CSE has a better enantiorecognition capability than CSD toward the tested drugs.A minority shareholder (Plaintiff) filed suit against a closely held corporation and the corporation’s board of directors, alleging that the directors engaged in oppressive conduct and breached their fiduciary duties by refusing to buy Plaintiff’s shares for fair value or meet with prospective buyers. CSD allowed partial or nearly baseline separation of amlodipine, laudanosine, nefopam, and sulconazole.
As observed, CSE allowed satisfactory separation of the enantiomers of amlodipine, laudanosine, nefopam, sulconazole, and tryptophan methyl ester, as well as partial resolution of citalopram, duloxetine, and propranolol under the optimized conditions. A variety of drug enantiomers were resolved in the buffer pH range of 2.8-3.4 using 20 mM Tris/ buffer with 5.0 % CSD or CSE and 20 kVapplied voltage.A central composite design was used to validate the optimized separation parameters and satisfactory uniformity was obtained. The effect of buffer composition and pH, chiral selector concentration, and applied voltage were systematically examined and optimized. In this paper, they were investigated for the first time for their potential as chiral selectors by CE. Chondroitin sulfate D (CSD) and chondroitin sulfate E (CSE), belonging to the group of glycosaminoglycans, are linear, sulfated polysaccharides with large mass.
Abstract : Received: 29 April 2013 /Revised: 3 October 2013 /Accepted: 29 November 2013 /Published online: 21 December 2013 Springer-Verlag Berlin Heidelberg 2013 Abstract Various chiral selectors have been utilized successfully in capillary electrophoresis (CE) however, the number of polysaccharides used as chiral selectors is still small and the mechanism of enantiorecognition has not been fully elucidated.
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